The calculated distance (air line) between Rheda-Wiedenbrück and Wuppertal is approximately 64 miles respectively 103 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Rheda-Wiedenbrück and Wuppertal has been calculated here.
Air line (approximately)
103 kilometers
56 nautical miles