The calculated distance (air line) between Essen and Neustadt an der Weinstraße is approximately 154 miles respectively 247 kilometers.
By car or train, the actual journey to Neustadt an der Weinstraße is certainly longer, as only the direct route (as the crow flies) between Essen and Neustadt an der Weinstraße has been calculated here.
Air line (approximately)
247 kilometers
134 nautical miles