The calculated distance (air line) between Leinefelde-Worbis and Wuppertal is approximately 138 miles respectively 221 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Leinefelde-Worbis and Wuppertal has been calculated here.
Air line (approximately)
221 kilometers
119 nautical miles