The calculated distance (air line) between Lauffen am Neckar and Wuppertal is approximately 175 miles respectively 281 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Lauffen am Neckar and Wuppertal has been calculated here.
Air line (approximately)
281 kilometers
152 nautical miles