The calculated distance (air line) between Cologne and Ludwigshafen am Rhein is approximately 120 miles respectively 193 kilometers.
By car or train, the actual journey to Ludwigshafen am Rhein is certainly longer, as only the direct route (as the crow flies) between Cologne and Ludwigshafen am Rhein has been calculated here.
Air line (approximately)
193 kilometers
104 nautical miles