The calculated distance (air line) between Huy-Neinstedt and Wuppertal is approximately 169 miles respectively 272 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Huy-Neinstedt and Wuppertal has been calculated here.
Air line (approximately)
272 kilometers
147 nautical miles