The calculated distance (air line) between Hofheim in Unterfranken and Wuppertal is approximately 167 miles respectively 268 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Hofheim in Unterfranken and Wuppertal has been calculated here.
Air line (approximately)
268 kilometers
145 nautical miles