The calculated distance (air line) between Hofheim am Taunus and Wuppertal is approximately 99 miles respectively 159 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Hofheim am Taunus and Wuppertal has been calculated here.
Air line (approximately)
159 kilometers
86 nautical miles