The calculated distance (air line) between Höchstädt an der Donau and Frankfurt am Main is approximately 134 miles respectively 216 kilometers.
By car or train, the actual journey to Frankfurt am Main is certainly longer, as only the direct route (as the crow flies) between Höchstädt an der Donau and Frankfurt am Main has been calculated here.
Air line (approximately)
216 kilometers
116 nautical miles