The calculated distance (air line) between Ginsheim-Gustavsburg and Karlsruhe is approximately 67 miles respectively 107 kilometers.
By car or train, the actual journey to Karlsruhe is certainly longer, as only the direct route (as the crow flies) between Ginsheim-Gustavsburg and Karlsruhe has been calculated here.
Air line (approximately)
107 kilometers
58 nautical miles