The calculated distance (air line) between Freiberg am Neckar and Wuppertal is approximately 185 miles respectively 297 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Freiberg am Neckar and Wuppertal has been calculated here.
Air line (approximately)
297 kilometers
160 nautical miles