The calculated distance (air line) between Frankfurt am Main and Sint-Oedenrode is approximately 173 miles respectively 278 kilometers.
By car or train, the actual journey to Sint-Oedenrode is certainly longer, as only the direct route (as the crow flies) between Frankfurt am Main and Sint-Oedenrode has been calculated here.
Air line (approximately)
278 kilometers
150 nautical miles