The calculated distance (air line) between Frankfurt am Main and Mariánské Lázně is approximately 179 miles respectively 287 kilometers.
By car or train, the actual journey to Mariánské Lázně is certainly longer, as only the direct route (as the crow flies) between Frankfurt am Main and Mariánské Lázně has been calculated here.
Air line (approximately)
287 kilometers
155 nautical miles