The calculated distance (air line) between Edingen-Neckarhausen and Wuppertal is approximately 140 miles respectively 225 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Edingen-Neckarhausen and Wuppertal has been calculated here.
Air line (approximately)
225 kilometers
122 nautical miles