The calculated distance (air line) between Düsseldorf and Ludwigshafen am Rhein is approximately 141 miles respectively 227 kilometers.
By car or train, the actual journey to Ludwigshafen am Rhein is certainly longer, as only the direct route (as the crow flies) between Düsseldorf and Ludwigshafen am Rhein has been calculated here.
Air line (approximately)
227 kilometers
122 nautical miles