The calculated distance (air line) between Buchholz in der Nordheide and Wuppertal is approximately 183 miles respectively 295 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Buchholz in der Nordheide and Wuppertal has been calculated here.
Air line (approximately)
295 kilometers
159 nautical miles