The calculated distance (air line) between Brake (Unterweser) and Wuppertal is approximately 154 miles respectively 248 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Brake (Unterweser) and Wuppertal has been calculated here.
Air line (approximately)
248 kilometers
134 nautical miles