The calculated distance (air line) between Bietigheim-Bissingen and Wuppertal is approximately 182 miles respectively 293 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Bietigheim-Bissingen and Wuppertal has been calculated here.
Air line (approximately)
293 kilometers
158 nautical miles