The calculated distance (air line) between Bernkastel-Kues and Wuppertal is approximately 93 miles respectively 149 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Bernkastel-Kues and Wuppertal has been calculated here.
Air line (approximately)
149 kilometers
80 nautical miles