The calculated distance (air line) between Annweiler am Trifels and Wuppertal is approximately 146 miles respectively 235 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Annweiler am Trifels and Wuppertal has been calculated here.
Air line (approximately)
235 kilometers
127 nautical miles