The calculated distance (air line) between Alzenau in Unterfranken and Wuppertal is approximately 116 miles respectively 187 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Alzenau in Unterfranken and Wuppertal has been calculated here.
Air line (approximately)
187 kilometers
101 nautical miles