The calculated distance (air line) between Neustadt an der Orla and Wiesbaden is approximately 160 miles respectively 258 kilometers.
By car or train, the actual journey to Wiesbaden is certainly longer, as only the direct route (as the crow flies) between Neustadt an der Orla and Wiesbaden has been calculated here.
Air line (approximately)
258 kilometers
139 nautical miles