The calculated distance (air line) between Neuburg an der Donau and Wiesbaden is approximately 162 miles respectively 260 kilometers.
By car or train, the actual journey to Wiesbaden is certainly longer, as only the direct route (as the crow flies) between Neuburg an der Donau and Wiesbaden has been calculated here.
Air line (approximately)
260 kilometers
140 nautical miles