The calculated distance (air line) between Neuburg an der Donau and Karlsruhe is approximately 128 miles respectively 206 kilometers.
By car or train, the actual journey to Karlsruhe is certainly longer, as only the direct route (as the crow flies) between Neuburg an der Donau and Karlsruhe has been calculated here.
Air line (approximately)
206 kilometers
111 nautical miles