The calculated distance (air line) between Heppenheim an der Bergstrasse and Wuppertal is approximately 129 miles respectively 208 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Heppenheim an der Bergstrasse and Wuppertal has been calculated here.
Air line (approximately)
208 kilometers
112 nautical miles