The calculated distance (air line) between Bischofsheim in der Rhön and Wuppertal is approximately 138 miles respectively 222 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Bischofsheim in der Rhön and Wuppertal has been calculated here.
Air line (approximately)
222 kilometers
120 nautical miles