The calculated distance (air line) between Bischofsheim in der Rhön and Karlsruhe is approximately 120 miles respectively 193 kilometers.
By car or train, the actual journey to Karlsruhe is certainly longer, as only the direct route (as the crow flies) between Bischofsheim in der Rhön and Karlsruhe has been calculated here.
Air line (approximately)
193 kilometers
104 nautical miles