The calculated distance (air line) between Seeheim-Jugenheim and Wuppertal is approximately 122 miles respectively 197 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Seeheim-Jugenheim and Wuppertal has been calculated here.
Air line (approximately)
197 kilometers
106 nautical miles