The calculated distance (air line) between Seeheim-Jugenheim and Karlsruhe is approximately 53 miles respectively 86 kilometers.
By car or train, the actual journey to Karlsruhe is certainly longer, as only the direct route (as the crow flies) between Seeheim-Jugenheim and Karlsruhe has been calculated here.
Air line (approximately)
86 kilometers
46 nautical miles