The calculated distance (air line) between Niefern-Öschelbronn and Wuppertal is approximately 177 miles respectively 285 kilometers.
By car or train, the actual journey to Wuppertal is certainly longer, as only the direct route (as the crow flies) between Niefern-Öschelbronn and Wuppertal has been calculated here.
Air line (approximately)
285 kilometers
154 nautical miles