The calculated distance (air line) between Niefern-Öschelbronn and Karlsruhe is approximately 18 miles respectively 30 kilometers.
By car or train, the actual journey to Karlsruhe is certainly longer, as only the direct route (as the crow flies) between Niefern-Öschelbronn and Karlsruhe has been calculated here.
Air line (approximately)
30 kilometers
16 nautical miles